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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
TheNativeAntigenCompany/Parvovirus VP2 Recombinant Protein/500ug/PV-VP2-500
产品编号:PV-VP2-500
市  场 价:¥12340.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$617.00
品      牌: TheNativeAntigenCompany
公      司:TheNativeAntigenCompany
公司分类:
TheNativeAntigenCompany/Parvovirus VP2 Recombinant Protein/500ug/PV-VP2-500
商品介绍

EM Images: Negative staining electron microscopy of Parvovirus VP2 virus-like particles (VLPs).

Parvovirus SDS-PAGE image

SDS-PAGE: Reducing SDS-PAGE gel showing purified Parvovirus B19 VP2 protein running with an expected MW of approximately 55-60kDa.

PARVOVIRUS VP2 RECOMBINANT PROTEIN

Parvovirus VP2 protein is a unique product that has been developed in response to the need for high purity, properly assembled Parvovirus antigens for use in the development of Parvovirus diagnostics and in vaccine development and R&D (including use as an immunogen). Parvovirus VP2 is produced in the form of Virus-like particles (VLP) in human cell lines using state-of-the-art expression techniques. Concentration and purification is then performed by a series of ultracentrifuge and precipitation methods which result in VLPs of exceptional quality and purity. The VP2 protein runs as a 60kD band on reducing SDS-PAGE.

PRODUCT DETAILS – PARVOVIRUS VP2 RECOMBINANT PROTEIN

  • Recombinant Parvovirus VP2 virus-like particles expressed from HEK293 cells (strain B19, NCBI Accession Number: AAB47793.1).
  • Includes amino acids 228-781 of the polyprotein and is buffered in Tris NaCl, pH7.9.
  • Greater than 95% purity by SDS-PAGE.

BACKGROUND

Virus-Like Particles (VLPs) are an emerging vaccine technology. VLPs consist of protein shells comprising outer proteins specific to the virus in question. VLPs are more representative of how viral antigens are presented in vivo and whilst they are highly immunogenic they are non-infectious as they lack the core genetic material of the virus. Another important advantage of VLPs is that they more effectively activate key aspects of the immune response to achieve potent immune stimulation and to provide immunological memory. VLP-based vaccines have also shown to provide effective protection and are in current use for several diseases and in development for many others.

Parvovirus disease in humans is generally a mild disease, which is sometimes known as Fifth Disease. It is characterised by a rash, which may be particularly prominent on the face and is sometimes known as a “slapped cheek rash”. Other symptoms are similar to those of the common cold, which usually precede the rash. In more severe cases there may be pain and swelling of the joints. The most serious potential side effect is anaemia caused by a decrease in erythropoiesis, which is a particular risk in immunocompromised patients. There is also a risk of miscarriage (approximately 10%) if a mother is infected in the first half of pregnancy. Parvovirus infection is spread by respiratory secretions, and is most contagious in the early stages of infection before a rash is present.

Certificate of AnalysisSafety Datasheet

品牌介绍

Native Antigen公司开发了专有的HEK293哺乳动物表达系统(VirtuE),用于表达重组蛋白。我们的  VirtuE系统能够引入适当的蛋白质折叠和完整的翻译后修饰,这对于完整的生物学和抗原活性至关重要。

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