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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
TheNativeAntigenCompany/Mayaro Virus VLP/500ug/REC31616-500
产品编号:REC31616-500
市  场 价:¥34620.00
场      地:美国(厂家直采)
产品分类: 诊断原料>免疫诊断>抗原>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$1731.00
品      牌: TheNativeAntigenCompany
公      司:TheNativeAntigenCompany
公司分类:
TheNativeAntigenCompany/Mayaro Virus VLP/500ug/REC31616-500
商品介绍

EM Images: Negative staining electron microscopy of MAYV virus-like particles (VLPs).

MAYARO VIRUS VLP

At The Native Antigen Company we have prepared recombinant Mayaro Virus VLP utilising our proprietary mammalian cell expression system. These particles contain Capsid and E1 and E2 envelope proteins. They will find application for researchers and assay developers who are looking to develop assays to distinguish Mayaro virus infection from Chikugunya virus.

PRODUCT DETAILS – MAYARO VIRUS LYSATE (TRVL4675 STRAIN)

  • Recombinant Mayaro virus-like particle (strain Acre27) comprising E1, E2 and Capsid proteins (NCBI Accession Numbers: AJA37502.1, KM400591.1), expressed from HEK293 cells.
  • Includes a mouse Fc-tag and is buffered in DPBS, pH7.4.
  • Suitable for use in immunoassay development.

BACKGROUND

Mayaro virus (MAYV) is a positive-sense single stranded RNA virus that belongs to the genus Alphavirus, a member of the Togaviridae family of viruses. It is a member of the Semliki Forest antigenic sero-complex, a serological group within the Alphavirus genus, and is closely related to Chikungunya virus (CHIKV) (Esposito, D.L.A).

Infection with Mayaro virus causes an acute, self-limited dengue-like illness of 3–5 days duration, characterized by fever, headache, myalgia, rash, prominent pain in the large joints, and association with rheumatic disease. MAYV is recognised as an emerging virus with the potential to cause a major epidemic in Central and South American countries. Currently, there is no licensed prophylactic vaccine or specific treatment for MAYV fever. Prevention of MAYV is through vector control measures to reduce transmission of the virus. Given the geographical distribution of MAYV and the similarity of the symptoms of Mayaro fever to infections caused by other arboviruses such Dengue fever, Chikungunya and Zika virus, it is considered important to be able to differentiate diagnostically between these arboviral diseases (CDC). Diagnosis of MAYV infection may be achieved by serological testing for MAYV specific IgM antibodies using enzyme immunoassays (EIA). However, cross reactivity with related viruses can reduce assay sensitivity and prevent accurate diagnosis (Figueiredo, ML).

REFERENCES

  • Esposito DLA and Fonseca BALD (2017). Will Mayaro virus be responsible for the next outbreak of an arthropod-borne virus in Brazil? Braz J Infect Dis.21(5):540-544
  • Center for Disease Control and Prevention: Emerging infectious diseases. Brunini, S et al (2017). High Frequency of Mayaro Virus IgM among Febrile Patients, Central Brazil. Research Letter. Volume 23, Number 6—June

Certificate of analysisSafety Datasheet

品牌介绍

Native Antigen公司开发了专有的HEK293哺乳动物表达系统(VirtuE),用于表达重组蛋白。我们的  VirtuE系统能够引入适当的蛋白质折叠和完整的翻译后修饰,这对于完整的生物学和抗原活性至关重要。

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