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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
TheNativeAntigenCompany/Dengue Virus Serotype 4 VLP/100µg/DENV4-VLP-100
产品编号:DENV4-VLP-100
市  场 价:¥12780.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$639.00
品      牌: TheNativeAntigenCompany
公      司:TheNativeAntigenCompany
公司分类:
TheNativeAntigenCompany/Dengue Virus Serotype 4 VLP/100µg/DENV4-VLP-100
商品介绍

Non-reducing SDS-PAGE gel showing purified Dengue virus serotype 4 virus-like particles; envelope protein (E) at approx. 55kDa, and prM protein running at approx. 17-18kDa.

DENGUE VIRUS SEROTYPE 4 VLP

Dengue Virus Serotype 4 VLP (Virus-Like Particle) is a new, unique product that has been developed in response to the need for highly immunogenic, concentrated Dengue antigens for use in Dengue focussed disease research and vaccine development (including use as an immunogen).

PRODUCT DETAILS – DENGUE VIRUS SEROTYPE 4 VLP

  • VLPs are constructed from E, M and preM proteins, with secretion from the cell aided by substituting the C terminal 20% with the corresponding Japanese Encephalitis Virus sequence (all internal/transmembrane).
  • Polyprotein amino acids 400-495 produced in HEK293 expression system and tested for stability.
  • Concentration and purification by a series of ultracentrifugation and chromatographical methods which result in VLPs of exceptional quality and purity.
  • Cleavage of preM protein occurs naturally by furin in the cell and results in a dual population of preM and M-containing VLPs.

BACKGROUND

Virus-Like Particles (VLPs) are an emerging vaccine technology. VLPs consist of protein shells comprising outer proteins specific to the virus in question. VLPs are more representative of how viral antigens are presented in vivo and while they are highly immunogenic they are non-infectious as they lack the core genetic material of the virus. Another important advantage of VLPs is that they more effectively activate key aspects of the immune response to achieve potent immune stimulation and to provide immunological memory. VLP-based vaccines have also shown to provide effective protection and are in current use for several diseases and in development for many others. With more than one-third of the world’s population living in areas at risk of transmission, dengue infection is a leading cause of illness and death in the tropics and subtropics (ref WHO for Guidelines for Diagnosis, Treatment, Prevention & Control, 2009) As many as 100 million people are infected yearly. Dengue is caused by any one of four related viruses transmitted by mosquitoes. There are no vaccines available to prevent infection with dengue virus. Please click here for other serotypes of VLP: Serotype 1, Serotype 2, Serotype 3.

Certificate of AnalysisSafety Datasheet

Publishing research using our reagents? Please let us know so that we can cite your publication as a reference.

1. Metz et al. (2018). Dengue virus-like particles mimic the antigenic properties of the infectious dengue virus envelope. Virol J. 2018 Apr 2;15(1):60 PMID: 29609659

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品牌介绍

Native Antigen公司开发了专有的HEK293哺乳动物表达系统(VirtuE),用于表达重组蛋白。我们的  VirtuE系统能够引入适当的蛋白质折叠和完整的翻译后修饰,这对于完整的生物学和抗原活性至关重要。

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